Chronological Aftercare Guide for Polynucleotides

If you’ve just had a Polynucleotide treatment at Kaizen Medical or you’re planning one soon—first off, welcome to the future of regenerative skincare! Polynucleotides are the next big thing in aesthetics, offering deep tissue rejuvenation, improved skin texture, and natural healing from the inside out. But as with any advanced injectable, what you do after your appointment can have a huge impact on your results.

Aftercare isn’t just about avoiding a few things for a couple of days—it’s about optimising your healing, supporting your body’s regenerative process, and getting the absolute best out of your treatment.

So whether you’re a first-timer or just need a refresher, here’s everything you need to know about Polynucleotide aftercare.

Before we dive into aftercare, let’s do a quick recap.

Polynucleotides are bio-stimulating injectable treatments made from purified DNA fragments (typically derived from salmon or trout sperm—don’t worry, they’re highly refined and safe). When injected into the skin, they act like a biological fertiliser – boosting cellular regeneration, increasing hydration, stimulating fibroblasts, and repairing damaged tissue.

They’re perfect for tackling:

• Skin laxity
• Dehydration
• Dark under-eyes
• Fine lines and wrinkles
• Acne scarring
• Redness and inflammation
• General dullness and skin fatigue

But remember—while the treatment works from the inside out, the aftercare you follow on the outside plays a big role in how beautifully your skin bounces back.

The first 24 hours after your Polynucleotide treatment are critical. This is the time when your skin is most sensitive and where you’ll want to be the most careful.

Avoid the following:

Touching your face unnecessarily: Your skin has tiny entry points where the needles were inserted. Keep your hands away to reduce the risk of introducing bacteria and causing infection.

Makeup of any kind: Let your skin breathe and allow the polynucleotides to settle into the tissues properly.

Hot environments: Such as saunas, steam rooms, or intense exercise. These can dilate blood vessels and potentially interfere with how the treatment integrates.

Alcohol: This can thin your blood and increase the risk of bruising and swelling.

Direct Sunlight or Sunbeds: your skin will be more photosensitive after treatment, and UV exposure could lead to inflammation or pigmentation issues.

Instead, opt for:

Cool compresses: (If needed) to calm any swelling.

Hydration: Inside and out. Drink plenty of water and use a light, hydrating serum if advised by your practitioner.

Gentle movement and rest: don’t plan anything intense or overly social that evening. Give your body time to start the healing process.

As your body begins responding to the polynucleotides, you may notice a few things—tiny lumps at the injection sites, a bit of puffiness, or even mild bruising. This is all totally normal and generally subsides within a few days.

Here’s what you should do:

Be patient: Unlike dermal fillers, which show instant volume, Polynucleotides work more gradually. You’re stimulating your body’s natural healing response, and that takes a little time.

Stick to simple skincare: Avoid any active ingredients like retinol, AHAs/BHAs, or Vitamin C until your practitioner gives the green light. Think fragrance-free cleansers, hyaluronic acid serums, and light moisturisers.

Skip exfoliation: Whether physical scrubs or chemical exfoliants—put them on pause for at least five days post-treatment.

Avoid vigorous massage or facial treatments: These can disrupt the placement of the product and irritate the skin.

If you experience any mild itching or tenderness, don’t panic—it’s a common part of the healing process. But if anything feels unusual, always reach out to your practitioner for advice.

One of the beautiful things about Polynucleotide treatments is the progressive, cumulative result. You won’t wake up the next day with a brand-new face—but over the next few weeks, your skin will gradually feel firmer, plumper, more hydrated, and more radiant.

Most people will start to notice visible improvements in:

Hydration and glow within the first 7–10 days

Skin texture and tone around the 2–3 week mark

Overall firmness and elasticity by week 4–6

For optimal results, a course of treatments is recommended—usually 2 to 3 sessions spaced 2–4 weeks apart, depending on your skin condition and goals.

During this time, supporting your skin from the inside out is essential. That means:

• Staying consistent with your water intake
• Prioritising sleep and reducing stress
• Eating a nutrient-rich, anti-inflammatory diet
• Avoiding smoking and excessive alcohol (both of which deplete collagen and slow regeneration)

After your initial course of treatments, maintenance is key to keeping your results looking fresh and radiant.

You can return for a top-up every 6–9 months, depending on your skin’s needs and how well you respond to treatment.

At home, a few things will help you maintain your new, healthier skin:

SPF every single day: Yes, even in winter. Polynucleotide treatments help repair and protect your skin, but UV rays are still the biggest cause of premature ageing.

Barrier-supporting skincare: Look for Ceramides, Niacinamide, and Peptides to keep your skin resilient.

A healthy sleep routine: Your skin regenerates overnight, and your body will continue working with the treatment for weeks after the final session.

Think of this as a partnership—you and your skin are working together with the polynucleotides to create lasting, natural-looking results.

While side effects are typically minimal, please reach out immediately if you experience:

• Persistent or spreading redness beyond 48 hours
• Significant swelling that worsens rather than improves
• Unusual discomfort or pain in the treated areas
• Lumps or irregularities that remain beyond 7 days
• Any concerns about your healing process

At Kaizen Medical, your treatment journey extends well beyond your appointment. Our team is always available to answer questions and ensure your complete satisfaction with your results.

Let’s wrap it up with the key takeaways:

Avoid makeup, hot environments, alcohol, and touching your face for the first 24 hours

No active skincare, sun exposure, or exfoliation for the first 3–5 days

Drink plenty of water and keep your skin hydrated

Be gentle with your skin—no massage or facials for at least a week

Wear SPF daily even on cloudy days

Maintain a healthy lifestyle to support your skin’s regenerative process

Stick to your treatment plan and follow up with maintenance every 6–9 months

Polynucleotides are one of the most exciting innovations in aesthetics—and when paired with the right aftercare, the results speak for themselves. At Kaizen Medical in Southampton, we specialise in advanced regenerative injectables designed to refresh, restore, and revive your skin naturally.

If you’re ready to experience the difference polynucleotides can make, we’d love to welcome you into the clinic. Book your consultation today and let’s start your journey to stronger, smoother, more radiant skin.